In the news


October 18, 2022

A novel statistical methodology for quantifying the spatial arrangements of axons in peripheral nerves

A thorough understanding of the neuroanatomy of peripheral nerves is required for a better insight into their function and the development of neuromodulation tools and strategies. Abida Sanjana Shemonti, Emanuele Plebani, Natalia P. Biscola, Deborah M. Jaffey, Leif A. Havton, Janet R. Keast, Alex Pothen, M. Murat Dundar, Terry L. Powley, and Bartek Rajwa in Bindley Bioscience Center, PU
August 10, 2022

Dr. Sintim’s lab in the Institute of Drug Discovery at Purdue University and the Bindley Bioscience Center Purdue Proteomics Facility (PPF) have published their research in the Journal “Molecules”

Millions of drug-resistant infections are reported annually in the U.S., with fatalities well over 30,000, and billions of dollars used annually in the treatment of such infections. The overuse of traditional antibiotics and slow introduction of new classes of antibacterial agents have contributed to the rising incidences of multidrug-resistant bacterial infections. A new paper from Sintim lab at the Purdue University's Institute for Drug Discovery in collaboration with the Purdue Proteomics Facility identifies a new class of alkynyl isoquinoline compounds with strong antibacterial activity against plethora of Gram-positive bacteria including Staphylococcus aureus. The finding was recently published in the journal "Molecules"
August 9, 2022

Dr. Andrisani’s lab in the college of Veterinary Medicine and the Bindley Bioscience Center Purdue Proteomics Facility (PPF) have published their research in the Journal “Frontiers in Immunology”.

Chronic Hepatitis B virus (HBV) infection is associated with liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The WHO reports more than 250 million people chronically infected with HBV, but current treatments are ineffective. Therefore, new and effective therapies are needed to achieve viral clearance. Dr. Andrisani's lab at Purdue University's College of Veterinary Medicine in collaboration with the Purdue Proteomics Facility have recently reported a proteomic study to explore a novel mechanism by which HBV evades innate immunity as a function of cell cycle progress. This study has been published in the Journal "Frontiers in Immunology".
July 18, 2022

Bindley Bioscience Center Purdue Proteomics Facility and Dr. Gaskill lab in Department of Animal Science have been published in the Journal of Proteomics

Protein profiles from used nesting material, saliva, and urine correspond with social behavior in group housed male mice, Mus musculus - ScienceDirect Current understanding of how odors impact intra-sex social behavior is based on those that increase intermale aggression. Yet, odors are often promoted to reduce fighting among male laboratory mice. www.sciencedirect.com
June 29, 2022

Dr. Uma Aryal, Research Assistant Professor in the Department of Comparative Pathobiology and the Director of Purdue Proteomics Facility, Bindley Bioscience Center, is a co-author on the manuscript “Photosystem stoichiometry adjustment is a photoreceptor mediated process in Arabidopsis”

Dr. Puthiyaveetil lab at Purdue Biochemistry has published a new paper on "Photosystem stoichiometry adjustment is a photoreceptor mediated process in Arabidopsis" that applied label-free quantitative proteomics. Dr. Uma Aryal, Research Assistant Professor in the Department of Comparative Pathobiology and the Director of Purdue Proteomics Facility is a co-author in this manuscript. Proteomics analysis was performed at the Purdue Proteomics Facility, Bindley Bioscience Center. Using light and redox signaling mutants, they reported that the light quality-responsive accumulation of photosystem I gene transcripts and proteins requires phytochrome B photoreceptor but not plastoquinone redox signaling as previously suggested.
June 23, 2022

Guest Editor: Dr. Uma Aryal, Department of Comparative Pathobiology and the Director of Purdue Proteomics Facility, Bindley Bioscience Center, is a guest editor of a special issue on “Functional Proteomics in Cell Biology and Beyond” to be published in the journal Molecules

Message from the Guest Editor Advances in proteomics have been driven by the development of new and advanced mass spectrometers as well as better algorithms and bioinformatics so????ware. The complementary coupling of mass spectrometry with different chromatographic separation techniques has improved the analysis of complex biological mixtures as well as the enhanced molecular characterization of proteins at the proteome or sub-proteome levels, and this information is being applied in the context of cell biology and diseases. Researchers investigating complex cell biology and diseases such as Alzheimer’s disease, neurodegenerative disease, diabetes, and cancer are taking advantage of these advanced proteomics technologies. Therefore, MS-based proteomics is now increasingly applied in many labs to address a large range of biological questions. In this Special Issue, we focus on the development and application of new and emerging proteomics technologies to study basic cell biology and diseases including biomarker discovery, molecular signaling, disease mechanisms, drug resistance, the roles and regulation of post-translational modifications, protein complexes, and interactions in cell biology and diseases.
June 11, 2022

Nanomaterials | Free Full-Text | Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition

Nanoparticles (NPs) interact with biomolecules by forming a biocorona (BC) on their surface after introduction into the body and alter cell interactions and toxicity. Metabolic syndrome (MetS) is a prevalent condition and enhances susceptibility to inhaled exposures. We hypothesize that distinct NP-biomolecule interactions occur in the lungs due to MetS resulting in the formation of unique NP ... Bindley Bioscience Center, Metabolomics Profiling and Purdue Proteomics Facility data acquired by Dr. Christina Ferreira and Dr. Uma Aryal