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Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic

Dr. Uma Aryal, Director of Purdue Proteomics Facility and Research Assistant Professor in the Department of Comparative Pathobiology contributed to this study and is a co-author. Proteomic studies were conducted at the Bindley Bioscience Center, Purdue Proteomics Facility.

February 9, 2022

Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation

Skeletal muscle is a heterogeneous and dynamic tissue that adapts to functional demands and substrate availability by modulating muscle fiber size and type. The concept of muscle fiber type relates to its contractile (slow or fast) and metabolic (glycolytic or oxidative) properties. Here, we tested whether disruptions in muscle oxidative catabolism are sufficient to prompt parallel adaptations in energetics and contractile protein composition. Bindley Bioscience Center, Metabolomics Facility, Dr. Christina Ferreira for lipidomics and metabolomics technical assistance

February 8, 2022

A single bout of cycling exercise induces nucleosome repositioning in skeletal muscle of lean and obese individuals – PubMed

Acute aerobic exercise improves, whereas being overweight impairs, skeletal muscle mitochondrial function in correlation with reduced insulin sensitivity. Here, the molecular and metabolic effects of a single exercise bout in the skeletal muscle was compared in men, aged 19-30 years, that were either… Bindley Bioscience Center, Metabolomics Profiling Facility materials and methods

January 24, 2022

Fat’s unexpected role in muscle stem cell fate

The Purdue team studied satellite cells, a stem cell population responsible for muscle development, growth and regeneration. In the adult muscle, these cells are maintained in a dormant state until there is an injury and they are called into action. Researchers used the Bindley Bioscience Center, Metabolomics Profiling Facility for Lipid Profiling

Maize Plants Chimeric for an Autoactive Resistance Gene Display a Cell-Autonomous Hypersensitive Response but Non–Cell Autonomous Defense Signaling

Purdue researchers and colleagues used Bindley Science Center's Genomics Core Facility service, WideSeq, to interrogate differences in the sequence of the gene Rp1-D21 in lesioned versus non-lesion sectors in several maize backgrounds

Purdue researchers leap to discover more about coronavirus

As the novel coronavirus pandemic grows, Purdue University researchers have launched more than 30 research projects and have applied for funding for nearly 20 additional projects.

February 26, 2020

Pancreatic cancer ‘time machine’ exposes plot twist in cell growth and invasion

Pancreatic cancer has one of the worst survival rates among cancers. Patients can expect as low as a 9% chance to live for at least five years after being diagnosed. Going back in time to observe how cells with key gene mutations interact and become invasive would help researchers better understand how the cancer starts and identify it sooner.

January 27, 2020

Getting cancer drugs to the brain is difficult – but a new ‘road map’ might make it easier

The human brain has some remarkable capabilities – including the ability to block cancer drugs from effectively reaching cancer cells in the brain. The greatest obstacle when it comes to treating cancer that has spread to the brain is the blood-brain barrier, the brain’s natural defense mechanism that is a collection of blood vessels that can filter out what goes in and out of the brain

January 10, 2020

Synthetic neurons project offers platform for disease treatment, further brain research

The body can recover from many things, but the damage caused by Parkinson’s disease isn’t one of them. No cure exists for Parkinson’s, which 1 million people in the U.S. are expected to be living with by 2020. But an outright cure isn’t the primary objective of research by Chongli Yuan, a Purdue University chemical engineering professor and leader of Purdue’s section of a multidisciplinary team studying the possibility of building synthetic neuron cells

December 12, 2019

An engineering approach to reduce the pain of chemotherapy

A study published in the American Journal of Managed Care states that the number of patients requiring first-line chemotherapy is expected to increase by more than 50%, from 9.8 million to 15 million, from 2018 to 2040. One of the most common side effects for those undergoing chemotherapy is peripheral neuropathy, a set of symptoms caused by damage to nerves that control the sensations and movements of arms, legs, hands and feet. The issue can be so intense in children that they can have trouble with simple handwriting and walking.