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Dr. Yokota's group at the Department of Biomedical Engineering, Indiana University Purdue University (IUPUI) and the Purdue Proteomics Facility in Bindley Bioscience Center have published their collaborative research on "Prostate Cancer-associated urinary proteome before and after prostatectomy" in the journal "Therapeutic Advances in Medical Oncology ". This study shows remarkable alteration of urinary proteome, and the post-prostatectomy urine provides tumor-suppressive proteomes and demonstrates the dynamic nature of urinary proteome as a strategy for predicting tumor suppressors.

Proteomic analysis of canine vaccines" has been published in the American Veterinary Medical Association (AVMA) that identifies mammalian proteins in commercial veterinary vaccines against canine distemper, leptospirosi, borreliosis, and rabies. This is a result of collaboration between scientists at the Purdue Proteomics Facility in Bindley Bioscience Center and Purdue College of Veterinary Medicine.

Laser-induced breakdown spectroscopy (LIBS) is an atomic-emission spectroscopy technique that employs a focused laser beam to produce microplasma. Although LIBS was designed for applications in the field of materials science, it has lately been proposed as a method for the compositional analysis of agricultural goods. We deployed commercial handheld LIBS equipment to illustrate the performance of this promising optical technology in the context of food authentication, as the growing incidence of food fraud necessitates the development of novel portable methods for detection. We focused on regional agricultural commodities such as European Alpine-style cheeses, coffee, spices, balsamic vinegar, and vanilla extracts. Liquid examples, including seven balsamic vinegar products and six representatives of vanilla extract, were measured on a nitrocellulose membrane. No sample preparation was required for solid foods, which consisted of seven brands of coffee beans, sixteen varieties of Alpine-style cheeses, and eight different spices. The pre-processed and standardized LIBS spectra were used to train and test the elastic net-regularized multinomial classifier. The performance of the portable and benchtop LIBS systems was compared and described. The results indicate that field-deployable, portable LIBS devices provide a robust, accurate, and simple-to-use platform for agricultural product verification that requires minimal sample preparation, if any. Spectroscopy System by Purdue University Xi Wu, Sungho Shin, Carmen Gondhalekar, Valery Patsekin, and J. Paul Robinson, Basic Medical Sciences, Euiwon Bae, Mechanical Engineering and Bartek Rajwa, Research Associate in Bindley Bioscience Center

The purpose of this study was to evaluate the effect of group discussion on the learning of mammalian physiology by nonmajor undergraduate students. Combining traditional lectures with group discussions increased the active participation of students in class and improved their learning of physiology, as measured by the results of in-semester and final examinations. The active learning technique benefited all class ranks on average. Purdue University Elikplimi K. Asem, Professor of Basic Medical Sciences and Bartek Rajwa, Research Associate Professor in Bindley Bioscience Center

Jing Yuan and Profs. Johnson, Ajuwon and Adeola, Animal Science, published a study including broiler chicken intestinal microbiome dynamics during Eimeria infection using 16S rRNA data generated in the Bindley Science Center's Genomics Core Facility

Cindy Nakatsu, Purdue Agronomy, and colleagues published a study of the alteration of the gut microbiome in postmenopausal women using MiSeq 16S data generated in the Bindley Science Center's Genomics Core Facility

Professor Mary Catherine Aime, Botany and Plant Pathology, with collaborators published a study of Sapwood mycobiomes in Nothofagus forests from Northern Patagonia using data generated in the Bindley Bioscience Center’s Genomics Core Facility

A thorough understanding of the neuroanatomy of peripheral nerves is required for a better insight into their function and the development of neuromodulation tools and strategies. Abida Sanjana Shemonti, Emanuele Plebani, Natalia P. Biscola, Deborah M. Jaffey, Leif A. Havton, Janet R. Keast, Alex Pothen, M. Murat Dundar, Terry L. Powley, and Bartek Rajwa in Bindley Bioscience Center, PU

Lipidomics analysis was performed in Metabolite Profiling Facility at Bindley Bioscience Center, Purdue University.

Millions of drug-resistant infections are reported annually in the U.S., with fatalities well over 30,000, and billions of dollars used annually in the treatment of such infections. The overuse of traditional antibiotics and slow introduction of new classes of antibacterial agents have contributed to the rising incidences of multidrug-resistant bacterial infections. A new paper from Sintim lab at the Purdue University's Institute for Drug Discovery in collaboration with the Purdue Proteomics Facility identifies a new class of alkynyl isoquinoline compounds with strong antibacterial activity against plethora of Gram-positive bacteria including Staphylococcus aureus. The finding was recently published in the journal "Molecules"