In the news

June 1, 2022

Variations in Intramuscular Fat Content and Profile in Angus × Nellore Steers Under Different Feeding Strategies Contribute to Color and Tenderness Development in Longissimus thoracis

Bindley's Metabolomics Analyst, Dr. Christina Ferreira co-author on biomarkers for discrimination of grass-from grain-fed beef

June 1, 2022

Equilibration solution composition and extended exposure to equilibration phase affect embryo development and lipid profile of mouse oocytes

Can exposure time to equilibration solutions during oocyte vitrification affect the lipid profile of oocytes and embryonic development? Could vitrification media supplemented with oleic, linoleic acids and L-carnitine effectively minimize damage induced by vitrification on embryo development and oocyte membrane lipid profile? Bindley Bioscience Center, Metabolomics Analyst, Dr. Christina Ferreira co-author

May 15, 2022

Suspect screening of exogenous compounds using multiple reaction screening (MRM) profiling in human urine samples

Thousands of chemical compounds produced by industry are dispersed in the human environment widely enough to reach the world population, and the introduction of new chemicals constantly occurs. As new synthetic molecules emerge, rapid analytical workflows for screening possible presence of exogenous compounds in biofluids can be useful as a first pass analysis to detect chemical exposure and guide the development and application of more elaborate LC-MS/MS methods for quantification. Bindley Bioscience Center, Metabolomics Analyst, Dr. Christina Ferreira - co-author

April 28, 2022

Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic

Dr. Uma Aryal, Director of Purdue Proteomics Facility and Research Assistant Professor in the Department of Comparative Pathobiology contributed to this study and is a co-author. Proteomic studies were conducted at the Bindley Bioscience Center, Purdue Proteomics Facility.

February 9, 2022

Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation

Skeletal muscle is a heterogeneous and dynamic tissue that adapts to functional demands and substrate availability by modulating muscle fiber size and type. The concept of muscle fiber type relates to its contractile (slow or fast) and metabolic (glycolytic or oxidative) properties. Here, we tested whether disruptions in muscle oxidative catabolism are sufficient to prompt parallel adaptations in energetics and contractile protein composition. Bindley Bioscience Center, Metabolomics Facility, Dr. Christina Ferreira for lipidomics and metabolomics technical assistance

February 8, 2022

A single bout of cycling exercise induces nucleosome repositioning in skeletal muscle of lean and obese individuals – PubMed

Acute aerobic exercise improves, whereas being overweight impairs, skeletal muscle mitochondrial function in correlation with reduced insulin sensitivity. Here, the molecular and metabolic effects of a single exercise bout in the skeletal muscle was compared in men, aged 19-30 years, that were either… Bindley Bioscience Center, Metabolomics Profiling Facility materials and methods

January 24, 2022

Fat’s unexpected role in muscle stem cell fate

The Purdue team studied satellite cells, a stem cell population responsible for muscle development, growth and regeneration. In the adult muscle, these cells are maintained in a dormant state until there is an injury and they are called into action. Researchers used the Bindley Bioscience Center, Metabolomics Profiling Facility for Lipid Profiling

July 21, 2021

Maize Plants Chimeric for an Autoactive Resistance Gene Display a Cell-Autonomous Hypersensitive Response but Non–Cell Autonomous Defense Signaling

Purdue researchers and colleagues used Bindley Science Center's Genomics Core Facility service, WideSeq, to interrogate differences in the sequence of the gene Rp1-D21 in lesioned versus non-lesion sectors in several maize backgrounds

March 31, 2020

Purdue researchers leap to discover more about coronavirus

As the novel coronavirus pandemic grows, Purdue University researchers have launched more than 30 research projects and have applied for funding for nearly 20 additional projects.

February 26, 2020

Pancreatic cancer ‘time machine’ exposes plot twist in cell growth and invasion

Pancreatic cancer has one of the worst survival rates among cancers. Patients can expect as low as a 9% chance to live for at least five years after being diagnosed. Going back in time to observe how cells with key gene mutations interact and become invasive would help researchers better understand how the cancer starts and identify it sooner.

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